factors that predict where miRNA binds include adenine and urasil-rich sequences, as well as the distance of target sites away from the center of long UTR's. Prior to this Hot Paper, researchers knew ...

MicroRNAs work by binding to complementary target sites ... Recently, researchers have begun to exploit endogenous miRNA regulation to target the expression of exogenously delivered genes and ...

In this interview, industry expert Dr. Lohit Khera discusses the evolving role of microRNA in research, diagnostics, and ...

Thus, animal miRNAs tend to regulate large target cohorts. Paradoxically ... For example, our studies identified transcription factors, RNA binding proteins, and signaling genes as critical miRNA ...

and the constitution and activity of such complexes could be specified by sequence-specific binding proteins that recognize parts of the microRNA (Fig. 2b, bottom). It will be important to ...

Dental caries (tooth decay) is a common oral health condition that often causes significant pain and discomfort and may even ...

The method also showed that some types of structures or mismatches in the binding process are more disruptive than others, an insight that could help researchers design better microRNA-based ...

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in understanding cancer biology.

Ph.D., they show that one RNA-binding protein on the cell surface, NPM1, could be a potent, selective target for treating acute myeloid leukemia (AML), as well as solid tumors. AML, a rapidly ...