Grey's Anatomy is one of the longest-running TV shows, and in this guide, we discuss what the cast is up to then vs now.

When Grey's Anatomy took off as a cultural phenomenon in the mid-2000s, Patrick Dempsey's Dr. Derek Shepherd also swiftly became one of the biggest heartthrobs on television. Nicknamed "McDreamy ...

Between Jason Isaacs' prosthetic penis, the two brothers hooking up and the cattiness of Jaclyn, Kate and Laurie in 'The ...

Kate Walsh played Derek Shepherd's ex-wife, Dr. Addison Montgomery, on the series from 2005-2012 Georgia Slater is a staff editor on the Parents team at PEOPLE. She has been working at PEOPLE ...

Shonda Rhimes considered creating a "Scandal" spinoff focusing on Eli Pope (Joe Morton) and additional spinoffs for "Grey's Anatomy." ...

Fans immediately fell in love with Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, George O’Malley, Derek Shepherd, Miranda Bailey, and more. Grey’s Anatomy is now in its 17th season ...

Shonda Rhimes initially thought the scandal surrounding Isaiah Washington’s 2007 firing would get ‘Grey’s Anatomy’ canceled ...

Isaiah Washington returned in Grey's Anatomy Season 10 offering Sandra Oh's Dr. Yang an entire cardiothoracic hospital in ...

Throughout the medical drama's run, Meredith Grey has mainly lived in two homes: the childhood home she inherited, with a constant rotation of roommates, and the dream house Derek Shepherd built ...

Would you lie with E! and just forget the world as we recount Grey's Anatomy's most heart-wrenching romances—including the Meredith Grey-Derek Shepherd pairing that breathed life into the ABC hit.