Scientists at Sanford Burnham Prebys and the Mayo Clinic used cryogenic electron microscopy to create 3D images detailing the overall structure of ubiquitous mitochondrial creatine kinase.

More information: Merve Demir et al, Structural basis for substrate binding, catalysis and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor, Structure (2025).

To ascertain the structure of uMtCK, the scientists captured images using cryogenic electron microscopy (cryo-EM). This technology enables investigators to create 3D images of proteins and their ...