observed that B2 gene of FHV resembles a plant virus gene encoding a silencing suppressor. Expression of the FHV B2 protein in plants prevented RNA silen ...

Both SGS3 and a viral suppressor of RNA silencing have now been shown to selectively bind 5′ overhang–containing dsRNA, implicating this RNA as a new intermediate in the RNA silencing pathway.

Instead, they rely on the RNA silencing system, which serves as their innate immune defense by recognizing and degrading viral RNA. In turn, viruses have evolved viral suppressors to inhibit the ...

Gene silencing by RNA interference is a ... that intravenous injection of antiviral small interfering RNA (siRNA) bound to a short virus-derived peptide offers protection against fatal viral ...

Multifunctional potyviral protein called helper component-proteinase (HCPro) is a suppressor of RNA silencing. We found that it induces RNA granules (PGs), which are required to overcome active RNA ...

The study shows that the virus manipulates a protein that normally helps regulate which genes should be active in the cell, turning this protein against the immune system. The protein, referred to as ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...