"By imaging the whole transcriptome at the individual transcript level and advancing sensitivity across any in situ RNA assay, these developments in CosMx represent a historic milestone in the study ...

Multi-modal data integration of single-nuclei RNA and ATAC sequencing with spatial transcriptomics, provides new molecular insights into gene regulatory networks driving cell state transitions in ...

Researchers in Nikolaus Rajewsky's lab at Max Delbrück Center combined high-resolution, single-cell spatial technologies to map a tumor's cellular neighborhoods in 3D and identify potential targets ...

CosMx SMI is spatial multiomics single-cell imaging solution. It enables rapid quantification and visualization of up to 1,000 RNA and 100 validated protein analytes at single-cell and subcellular ...

Methods: We performed following assays including 1) High-plex multiple IHC platform: PhenoCycler Fusion (PCF) protein-level spatial analysis (n=10), 2) FFPE Single-Cell RNA Sequencing (FFPE scRNA-seq) ...

Spatial transcriptomics using the Digital Spatial Profiler was employed to analyze gene expression separately for epithelial and sarcomatoid tumor components. Single-cell RNA sequencing (scRNA-seq) ...

This review integrates recent advancements in single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to elucidate glioblastoma’s cellular heterogeneity and metabolic reprogramming. Diverse ...

Liu et al., present glmSMA, a network-regularized linear model that integrates single-cell RNA-seq data with spatial transcriptomics, enabling high-resolution mapping of cellular locations across ...