Why is knowing the atomic structure of molecules useful? Learn why, and how information like this about protein structure is shared through a publicly available database.

A gene known as HbS was the center of a medical and evolutionary detective story that began in the middle 1940s in Africa. Doctors noticed that patients who had sickle cell anemia, a serious ...

In sickle-cell disease, a single nucleotide change within the haemoglobin beta subunit gene — swapping out the amino acid glutamate for valine — gives rise to defective molecules with ...

Sickle cell conditions are genetic blood disorders that affect haemoglobin, the molecule in red blood cells responsible for carrying oxygen throughout the body. While both sickle cell trait and ...

Novo Nordisk has doubled down on position in the sickle cell disease (SCD ... and result from abnormal production or structure of haemoglobin in red blood cells. Etavopivat is an oral selective ...

The abnormal haemoglobin (HbS), causes red blood cells to change their structure and become like ... To be born with sickle cell disease, a child has to inherit a copy of the sickle cell gene ...

Sickle cell is an inherited disease which leads to the formation of impaired haemoglobin and, in turn, ‘sickling’ of red blood cells. These misshapen cells can then block small blood vessels ...

Sickle cell disease is a genetic blood disorder characterised by the presence of abnormal haemoglobin (Hb ... and economic deprivation have on brain structure. This may lead to treatments ...

SCD affects many parts of the body, and is associated with severe painful crises. People with sickle-cell anaemia have a type of haemoglobin (called haemoglobin S (HbS) or sickle haemoglobin) which ...

Sickle-cell anaemia is also referred to as "HbSS", "SS disease", "haemoglobin S" or permutations thereof. In heterozygous people, who have only one sickle gene and one normal adult haemoglobin ...

A new drug called Voxelotor which alleviates the symptoms of sickle cell disease has been described as "life-changing". It works by helping haemoglobin hold on to more oxygen and prevent them from ...