Andrew Fire and Craig Mello first demonstrated RNAi in C. elegans in 1998, a discovery recognized in 2006 when they won the Nobel Prize in Physiology or Medicine.1 Interest exploded in 2001 when ...

RNAi in Plants I take exception with your claim in The Scientist1 that RNAi was first discovered in Caenorhabditis elegans. While the term "RNAi" was first coined by Fire and colleagues,2 several ...

Figure 2: A model for RNAi/PTGS/quelling. Several laboratories that study C. elegans have initiated genome-wide screens, based on an RNAi approach, to identify genes essential for completion of ...

Oregon Health & Science University, in collaboration with Oregon State University, has discovered the structural organization ...

Our search for additional microRNAs was precipitated by Pasquinelli and Ruvkun's finding that the let-7 RNA sequence is perfectly ... developmental switch in C. elegans. Cell 57, 49–57 (1989).

the C. elegans ortholog of TDP-43, results in an abnormal accumulation of double-stranded RNA (Saldi et al, 2014). We are currently testing the hypothesis that loss of TDP-43 nuclear function, as well ...