the antisense strand has to be incorporated into the RNA-induced silencing complex (RISC). It turns out that the relatively low thermodynamic stability in the 5′ end of the antisense siRNA ...

RNA silencing processes result in the sequence-specific degradation of RNA and effective post-transcriptional gene silencing. In the May 17 Science, Hongwei Li and colleagues from the University of ...

The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA ... activity means that miRNA can act on many different mRNAs, potentially silencing hundreds of ...

Instead, they rely on the RNA silencing system, which serves as their innate immune defense by recognizing and degrading viral RNA. In turn, viruses have evolved viral suppressors to inhibit the ...

Only one strand of the miRNA:miRNA* duplex or the siRNA duplex is preferentially assembled into the RNA-induced silencing complex (RISC) , which subsequently acts on its target by translational ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

They observed that introducing double-stranded RNA (dsRNA) into the worm led to the silencing of genes with complementary sequences. This discovery laid the foundation for understanding the mechanism ...