The San Francisco 49ers (6-10) are 4.5-point underdogs as they try to break their three-game losing streak in a matchup against the Arizona Cardinals (7-9) on Sunday, January 5, 2025 at State Farm

The San Francisco 49ers (6-10) and Arizona Cardinals (7-9) will look to wrap up their seasons on a high note when the meet Sunday in a Week 18 battle of teams that have been eliminated from the playoff picture.

The 49ers vs. Cardinals game starts at 1:25 p.m. PT and can be seen on Fox. Play-by-play broadcaster Chris Myers and color analyst Mark Schlereth will call the game from the booth at State Farm Stadium, with Jen Hale reporting from the sidelines.