Ferroptosis, a form of programmed cell death mediated by iron, has been a focus for its potential in cancer therapies. Now, ...

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death.

More information: Yuma Saimoto et al, Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization, Nature Communications (2025). DOI: 10.1038/s41467 ...

New research has found that lipid peroxidation of lysosomes plays a critical role in the execution of ferroptosis.