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Enzyme-resistant glycan glue ameliorates spinal disk degeneration in animal models
As the world's population ages, intervertebral disk degeneration (IDD) has become a major medical issue, causing chronic ...
Revealing the key player in oral submucous fibrosis: Could COMP be the solution?
Oral submucous fibrosis (OSF) is a serious disease that impairs mouth functionality, often leading to restricted opening and ...
Medscape25d
Technology Insight: Adult Mesenchymal Stem Cells for Osteoarthritis Therapy
We first address the etiopathophysiology of OA and the mechanisms responsible for breakdown of the cartilage extracellular matrix. We then discuss the potential of MSCs for articular cartilage ...
C&EN1mon
Bioinspired Lipid Nanoparticles with Prolonged Cartilage Retention Boost Regeneration in Early Osteoarthritis and Large Cartilage Defects
Medical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University, Hangzhou 311115, China Key Laboratory of Biomechanics and Mechanobiology ...
eLife1mon
Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines
Invitrogen Cat# MA137493 Detects cartilage matrix in immunofluorescence (1:200) Antibody Anti-Collagen I (Rabbit monoclonal) Abcam Cat# ab138492 Used for extracellular matrix immunostaining (1:200) ...
C&EN1mon
Enhanced Ear Cartilage Regeneration with Dual-Network LT-GelMA/F127DA Hydrogel Featuring Nanomicelle Integration
(28−30) The primary objective of this study is to investigate the efficacy of a novel dual-network hydrogel system composed of LT-GelMA and F127DA in promoting the regeneration of ear cartilage ...
Frontiers1mon
Non-coding RNA in cartilage regeneration: regulatory mechanism and therapeutic strategies
Hyaline cartilage, elastic cartilage ... In summary, the factors influencing cartilage regeneration include the extracellular matrix, mechanical loading, and genetic regulation, all of which ...
ahajournals.org6y
Vitamin K–Dependent Matrix Gla Protein as Multifaceted Protector of Vascular and Tissue Integrity
Step 4: p-cMGP is secreted into the extracellular matrix or the circulation to inhibit soft tissue calcification, VSMC (vascular smooth muscle cell) trans-differentiation into OPC (osteochondrogenic ...