Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India ...

Using its proprietary FBDD platform, Blacksmith discovered FG-2101, the prodrug form of FG-960, the first known non-hydroxamate LpxC inhibitor that exerted activity against LpxC at the nanomolar range ...

iterative rounds of optimization inside REAL Space possess far reaching potential for drug development targeting Gram-negative bacteria as a whole. Previously, our lab identified natural product ...

Purpose. The appropriateness of combination therapy for infections caused by gram-negative organisms is examined. Summary. Mortality from Pseudomonas aeruginosa infection is particularly high ...

This study aimed to investigate the activity of colistin in combination with the anti-rheumatic drug auranofin against Col-R Gram-negative bacteria. The results of checkerboard analysis demonstrated ...

The prediction of antimicrobial resistance in Gram-negative bacteria, often the cause of serious systemic infections, is more challenging as genotype-to-phenotype (drug resistance) relationship is ...

We conducted a systematic review and meta-analysis of published studies to summarize the effect of appropriate antibiotic therapy (AAT) or IAT against gram-negative bacterial infections in the ...