Cleveland already lost against the hungry Pacers when they had both Mobley and Hunter available. Without them, it'll likely take a Herculean effort from Cavaliers like Donovan Mitchell to have any reasonable chance of avoiding a disastrous 0-2 hole after losing the first two home games.

Bennedict Mathurin soars up in the air for the block on De'Andre Hunter (with replays). Kenny Atkinson will challenge the out of bounds call, in order to challenge on the play prior, as he thinks Mathurin fouled Hunter. pic.twitter.com/cwxdpJbiFF

The Cavaliers remained relatively free of injuries to key players during the regular season. But now, it seems, pain has set in, and at the worst possible time.