Our study identified CDKN1A+ senescent cells across four liver-resident cell types, namely hepatocytes, fibroblasts, cholangiocytes, and liver sinusoidal endothelial cells, with their prevalence ...

Go to source). However, researchers at Keio University, led by Ryo Igarashi and Mayumi Oda, developed a breakthrough method using cryopreserved human hepatocytes. By treating them with oncostatin ...

When prioritizing growth and survival in laboratory settings, hepatocytes, the liver's main cells, eventually transformed into cells resembling cholangiocytes, which line the bile duct. Hepatocyte ...

ORM2 gene expression was increased in biliatresone-challenged, bile acid-challenged and acetaminophen-challenged cholangiocytes. Cholangiocyte-derived ORM2 induced unique transcriptome changes and ...

Automated and manual paraffin embedding (2 automated tissue processors, 1 manual embedding station, 1 paraffin oven). Cryo-sectioning, plastic sectioning, and vibratome sectioning for diverse sample ...

This project focuses on understanding how epigenetic dysregulation in cholangiocytes leads to the release of paracrine molecules that subsequently activate myofibroblasts. In particular, the project ...

School of Mechanical Engineering, Dongguan University of Technology, Songshan Lake, Dongguan 523820, China Institute of Science&Technology Innovation, Dongguan University of Technology, Songshan Lake, ...

HistoSeg is an Encoder-Decoder DCNN which utilizes the novel Quick Attention Modules and Multi Loss function to generate segmentation masks from histopathological images with greater accuracy. This ...