A recent review highlights the critical role of glutathione S-transferases (GSTs) in human health, emphasizing their ...

A research group led by Prof. Chen Liang at the Ningbo Institute of Materials Technology and Engineering (NIMTE) of the ...

Click chemistry efficiently ligates molecular building blocks in a robust and high-yielding manner and has found major application in the rapid modification of important molecular actors in biological ...

Historically, small molecule drugs have been precisely designed down to the atomic scale. Considering their relatively large complex structures, nanomedicines have lagged behind. Researchers argue ...

This account aims to explore the results obtained by our group over the years surrounding the synthesis and biological evaluation ... chain of events only possible given its unique chemical structure.

State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China ...

The nucleosides are rich in exposed hydroxyl and amino groups, so scientists use protecting groups to prevent unintended reactions with compounds used in DNA synthesis. Chemicals remove the protecting ...

ChemCrow is designed to autonomously carry out chemical synthesis jobs. It is built on large language models (LLMs), such as GPT-4, supplemented by LangChain for tool integration. The scientists added ...

Consequently, they are fundamental components of our bodies and vital for physiological functions such as protein synthesis, tissue repair and nutrient absorption. Here we take a closer look at amino ...

Evidence of the depletion of glutathione (GSH) and increased oxidized GSH can be ... resulting in insufficient GSH synthesis. Acyl-CoA synthetase long chain family member 4 (ACSL4) catalyzes the ...