The cell must also pass through a series of checkpoints that ensure conditions are favorable for division. In order to move from one phase of its life cycle to the next, a cell must pass through ...

factors involved in maintenance of cell cycle checkpoints, and proteins required for apoptosis induction. The types of genetic alterations leading to pRb inactivity most often involve frameshifts ...

From this and other discoveries, including the discovery of the RAD9 gene with former postdoc Ted Weinert, Hartwell hypothesized that checkpoints regulate the sequence of events in mitosis.1 His ...

In this role-playing game, students act as cells (healthy and cancerous) and go through the cell cycle, while some students play the roles of checkpoint proteins. This experience deepens their ...