Background IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models ...

Systemic therapy represents the standard of care treatment for patients with advanced hepatocellular carcinoma (HCC). Given the increased risk of death from cirrhosis-related complications in patients ...

Background Inflammatory bowel diseases (IBDs) are characterised by dysbiosis and a leaky gut. The NADPH oxidase dual oxidase 2 (DUOX2) is upregulated in patients with IBD, yet its role in driving the ...

Objective Both the gut microbiome and host genetics are known to play significant roles in the pathogenesis of IBD. However, the interaction between these two factors and its implications in the ...

Professor M Trevisan, Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, 270 Farber Hall, 3435 Main Street, Buffalo, New York 14214–3000, USA. Email: trevisan{at ...

1 Department of Paediatrics, University of Naples Federico II, Naples, Italy and European Laboratory of Food Induced Disease (ELFID), Naples, Italy Background and aims: The genetic load in coeliac ...

2 Department of Pathology, School of Forensic Medicine, Shanxi Medical University, Taiyuan, China 3 Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science ...

Objective Although immunoglobulin A (IgA) is abundantly expressed in the gut and known to be an important component of mucosal barriers against luminal pathogens, its precise function remains unclear.

Mr C P Barham, University Department of Surgery, Bristol Royal Infirmary, Bristol BS2 8HW, UK. Background—Diffuse oesophageal spasm (DOS) is a potential cause of intermittent chest pain and/or ...

This paper presents evidence for the existence in extracts from porcine non-antral gastric tissue of a peptide capable of causing substantial rises of plasma immunoreactive gastrin levels in a dose ...

Objectives National guidelines for the management of irritable bowel syndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there ...