Cancer Research6d
A Phase II Study of Acimtamig (AFM13) in Patients with CD30-Positive, Relapsed, or Refractory Peripheral T-cell Lymphomas
This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons ...
Cancer Research7d
Comparison of Shared Class I HLA-bound Non-canonical Neoepitopes between Normal and Neoplastic Tissues of Pancreatic Adenocarcinoma
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Cancer Research7d
Novel Degrader Shows Anti–Lymphoma and Myeloma Activity
The cereblon E3 ligase modulator cemsidomide showed activity against multiple myeloma and two types of non–Hodgkin lymphoma in a phase I study.
Cancer Research7d
EZH2 Inhibition Enhances T-cell Immunotherapy in B Cell Lymphoma
Major Finding: Pharmacologic inhibition of EZH2 sensitizes preclinical models of B cell lymphoma to T-cell immunotherapy. Concept: EZH2 inhibition enhances T-cell recruitment, T-cell–B-cell ...
Cancer Research7d
Stratified Medicine Paediatrics: Cell free DNA and serial tumour sequencing identifies subtype specific cancer evolution and epigenetic states
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Cancer Research7d
ALK TKI Earns FDA Approval
The ALK tyrosine kinase inhibitor (TKI) ensartinib (Ensacove; Xcovery) was approved for patients with locally advanced or metastatic ALK-positive non–small cell lung cancer (NSCLC). The decision was ...
Cancer Research8d
Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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Cancer Research8d
The Menstrual Cycle Regulates Chemotherapy Response in Breast Cancer
Major Finding: In breast cancer, chemotherapy elicits stronger antitumor responses when administered during estrus. Concept: The estrous cycle alters macrophage infiltration, epithelial-mesenchymal ...
Cancer Research9d
Toward Better Patient Stratification with Machine Learning
Machine learning could better stratify patients with metastatic ER-positive, HER2-negative breast cancer who are more or less likely to benefit from CDK4/6 inhibition up front. At Memorial Sloan ...
Cancer Research9d
Aging Hinders Tumorigenesis by Disrupting Stemness and Iron Homeostasis
Major Finding: Aging impedes lung tumorigenesis by limiting the stemness of the alveolar type 2 cell of origin. Concept: The effect of age on tumorigenesis is mediated by a disruption of iron ...
Cancer Research10d
The tumor immune microenvironment and therapeutic efficacy of trastuzumab deruxtecan in gastric cancer
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Cancer Research10d
FDA Approval Summary: Polatuzumab Vedotin in the First-Line Treatment of Select Large B-Cell Lymphomas
1Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. *Corresponding Author: Maryam Sarraf Yazdy, U.S. Food and Drug Administration, WO22 Room 2169, ...