What happened to Kelsey Grammer’s sister Karen? Learn how her tragic 1975 murder shaped his life and inspired his new memoir, "Karen: A Brother Remembers."

Kelsey Grammer says that he drank, used drugs, and engaged in 'fairly exotic sexual behavior' to cope with the horrific murder of his sister Karen in 1975: 'A lot of fun and then the fun ran out.'

Kelsey Grammer is opening up about the 1975 murder of his sister, Karen Grammer, in his new book "Karen: A Brother Remembers."