Scientists at Sanford Burnham Prebys and the Mayo Clinic used cryogenic electron microscopy to create 3D images detailing the overall structure of ubiquitous mitochondrial creatine kinase.

More information: Merve Demir et al, Structural basis for substrate binding, catalysis and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor, Structure (2025).

Comparison of the electrophoretic patterns of creatine kinase in different birds throws some light on the type of evolutionary changes which have affected the multiple forms of this enzyme.

To ascertain the structure of uMtCK, the scientists captured images using cryogenic electron microscopy (cryo-EM). This technology enables investigators to create 3D images of proteins and their ...