Patricia Arquette and Thomas Jane are breaking up – again. Despite working through a separation last year, the Medium actress and Hung actor have decided to get a divorce, his rep tells PEOPLE.

High Desert' Star Harlow Jane 'Rebelled Against' Parents Patricia Arquette and Thomas Jane's Path (Exclusive) Patricia Arquette Recalls Failed 'Jerry Maguire' Audition with Tom Cruise ...

Actress Anne Heche and her former Hung costar Thomas Jane are dating ... married to actress Aysha Hauer as well as actress Patricia Arquette, with whom he shares daughter, Harlow, 16.

High Desert' Star Harlow Jane 'Rebelled Against' Parents Patricia Arquette and Thomas Jane's Path (Exclusive) Anne Heche's Exes James Tupper and Thomas Jane Send 'Thoughts and Prayers' After Fiery ...