Parkinson’s affects the substantia nigra, a part of the brain that produces dopamine. As this dopamine supply dwindles, so does the brain's ability to coordinate muscle movements—including those ...

This valuable study reveals the pro-locomotor effects of activating a deep brain region containing diverse range of neurons in both healthy and Parkinson's disease mouse models. While the findings are ...

"We saw an increase of blacker spots in a particular region of the midbrain associated with psychosis –the substantia nigra and ventral tegmental areas. This increase was seen in those with ...

Parkinson’s disease (PD) is a neurodegenerative disease of the central nervous system characterized by the loss of dopaminergic neurons in the substantia nigra and the abnormal aggregation of ...

5 Department of Neurosurgery, St Vincent’s Hospital, Fitzroy, VIC, Australia 6 Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia 7 Department of Medicine, The University of ...

Magnetic resonance imaging revealed periaqueductal edema involving medial substantia nigra. [18 F]dopa positron emission tomography demonstrated reduced uptake in the caudate and putamen with relative ...

Alzheimer's Disease (AD) is characterized by a host of recognizable cognitive symptoms, but many non-cognitive symptoms like sleep changes, anxiety, and depression can be early signs of the disease.

Then, from each brain, they collected a sample of the noradrenaline-producing locus coeruleus (LC) – a region that is highly vulnerable to Alzheimer’s – and the dopamine-producing substantia nigra (SN ...

In contrast, beta power in the subthalamic nucleus of Parkinson’s disease (PD) patients did not differ significantly between the incongruent and the congruent orientation of the center-out task.

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the presence of α-synuclein (α-Syn)-rich Lewy bodies (LBs) and the preferential loss of dopaminergic (DA) neurons ...