Parkinson’s affects the substantia nigra, a part of the brain that produces dopamine. As this dopamine supply dwindles, so does the brain's ability to coordinate muscle movements—including those ...

Hotchkiss Brain Institute, University of Calgary, Calgary, Canada Department of Neuroscience, University of Calgary, Calgary, Canada Faculty of Veterinary Medicine, University of Calgary, Calgary, ...

This valuable study reveals the pro-locomotor effects of activating a deep brain region containing diverse range of neurons in both healthy and Parkinson's disease mouse models. While the findings are ...

"We saw an increase of blacker spots in a particular region of the midbrain associated with psychosis –the substantia nigra and ventral tegmental areas. This increase was seen in those with ...

Oxidative stress in PD underlies the formation and spread of α-synuclein (αSyn)-rich aggregates, known as Lewy bodies, which are thought to induce degeneration of dopaminergic neurons in the ...

Parkinson’s disease (PD) is a neurodegenerative disease of the central nervous system characterized by the loss of dopaminergic neurons in the substantia nigra and the abnormal aggregation of ...