"We think the bacteria's ribosomes might be altering its structure just enough to prevent an antibiotic from binding effectively," says Anna Delgado-Tejedor, first author of the study and Ph.D ...

These differences are exploited by antibiotics, which are designed to inhibit the prokaryotic ribosomes of infectious bacteria without affecting eukaryotic ribosomes, thereby not interfering with ...

Bacteria modify their ribosomes when exposed to widely used antibiotics, according to research published today in Nature Communications. The subtle changes might be enough to alter the binding ...

Lariocidin hits drug-resistant bacteria where others fail — by hijacking the ribosome at a new site, bypassing defences, and opening the door to a new generation of antibiotics. Lariocidin ...

none were previously known to target the bacterial ribosome—the protein-making machinery itself. Gerry Wright and his research team discovered lariocidin by examining soil samples from a ...

Proteins form the structural and functional backbone of the cell, and any perturbation in their synthesis can disrupt normal ...

"No one knew that lasso peptides could bind to the ribosome and kill bacteria by not allowing them to make new proteins." Because lariocidin binds at a site different from where other antibiotics ...

Lariocidin can directly attach to a complex that generates proteins in cells, called the ribosome, in a novel way. When lariocidin binds to the bacterial ribosome, protein synthesis is prevented, and ...

What if we could fight climate change using bacteria that live on air? That's the vision behind a newly funded international research project led by ...

Williams and Research Scientist Anton Petrov compared three-dimensional structures of ribosomes from a variety of species of varying biological complexity, including humans, yeast, bacteria and ...