Pyruvate dehydrogenase (PDH) is a mitochondrial multiunit complex which catalyzes pyruvate oxidation (derived mainly from glucose) to acetyl-CoA which then enters tricarboxylic acid cycle. Its ...

Lily Cieslinski was diagnosed with Pyruvate Dehydrogenase Complex Deficiency in 2024. Her parents held a fundraiser to support research just two months later.

Here they show that reduced pyruvate dehydrogenase (PDH) activity lowers locomotion but extends lifespan in daphnids and show that inhibition of PDH can increase lifespan in these species.

Cartoon summarizing the principal metabolic pathways deregulated in Autosomal Dominant Polycystic Kidney Disease, including glycolysis, glutamine anaplerosis, TCA cycle, OXPHOS and other central ...

Spain continues its unbeaten streak in the FIM X-Trial of Nations. Toni Bou (Repsol Honda Trial Team) achieved a record-equaling ninth gold, while his teammate Jaime Busto (GasGas) celebrated his ...

Mayo Clinic Hospital-Rochester, Rochester, MN.

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China ...