Oddsmakers project the San Francisco 49ers (6-10) to put up a fight in their attempt to break their three-game losing streak, ...

Ricky Pearsall is looking forward to a special homecoming as the Arizona Cardinals host San Francisco in the 2024 ...

This NFC West showdown features a matchup between two disappointments. The San Francisco 49ers were expected to compete for a ...

Head coach Kyle Shanahan told reporters Thursday that Purdy will not play Week 18 against the Arizona Cardinals. Purdy ...

The NFC West was turned upside down this season, as the San Francisco 49ers have been eliminated from the playoffs just one season removed from a trip to the Su ...

The 49ers have ruled out two key starters versus the Cardinals in the regular season finale. Deebo Samuel and Deommodore ...

The Deebo Samuel Era with the 49ers may have just come to an abrupt end. Samuel will miss the 49ers' season finale against ...

Preview the Week 18 matchup between the Arizona Cardinals and San Francisco 49ers with predictions, odds, over/under, spread, betting lines and more.

The 49ers entered the season as the NFC West betting favorites, and mid-season it seemed like the Cardinals were primed to contend for the crown, but as we get ...

The 49ers will wrap up a massively disappointing season without a number of starters when they face the Cardinals in Week 18.

Will the 49ers pull off an upset against the Cardinals? Discover fan and staff predictions for this divisive Week 18 NFC West showdown.

Matt Maiocco lists five 49ers to watch in San Francisco’s season finale matchup with the Arizona Cardinals on Sunday.