Epigenetic reprogramming holds promise for reversing aging, addressing cellular aging mechanisms and paving the way for innovative therapeutic strategies.

Among the major classes of RNAs in the cell, tRNAs remain the most difficult to characterize via deep sequencing approaches, as tRNA structure and nucleotide modifications can each interfere with cDNA ...

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ-PKAc fusion oncoprotein. However, the underlying mechanism of DNAJ-PKAc’s ...

Tda1 protein kinase, activated by Snf1 and yeast GSK3-β, fine-tunes metabolism through the phosphorylation of Hxk2, which is implicated in yeast glucose repression. Tda1 is activated by both Snf1 and ...

A massive, multi-year project led by over 150 scientists has produced the most detailed map yet of how visual information travels through the brain – revealing more than 500 million connections in a ...

The international community has a golden opportunity to start reining in the escalating, mostly ignored global burden of chronic kidney disease. The genetic bases of the seven pairs of contrasting ...

Outside magazine The idea behind sleepmaxxing — getting sufficient, good quality sleep — isn’t new, says Aruna Rao, assistant professor of neurology at Johns Hopkins Medicine. “People are finally ...

In his postdoctoral work in the laboratory of Andrea Musacchio at the IFOM-IEO campus in Milan, he focussed on the role of kinetochore proteins in chromosome segregation. Hartmut joined The EMBO ...