Roeck et al. show that ferroptosis spreads between neighboring cells via lipid peroxidation across adjacent membranes. Cell contact and extracellular iron are key factors, highlighting a potential ...

The key cyclization of an allylic alkoxyl radical to a carbon-centered allylic radical had been detected earlier (3) and has subsequently been recognized as a "key step in hydroperoxide-amplified ...

The investigators then demonstrated that the dysregulation of this metabolic pathway led to increased lipid peroxidation—a process that damages cellular membranes and may trigger neuronal death.