These mice exhibit a severe bleeding tendency and a leukocyte adhesion defect reminiscent to the phenotype in LAD-III patients. Kindlin-3 belongs to a family of three cytoplasmic proteins ...

Patients in the EU with Fanconi anaemia ... from the FDA on Kresladi (marnetegragene autotemcel) for severe leukocyte adhesion deficiency-I (LAD-I), its lead product, which is due by 30th June ...

The company is developing its gene therapy candidate, Kresladi (marnetegragene autotemcel) to treat patients with severe leukocyte adhesion deficiency-I (LAD-I), a rare genetic disorder.

today announced the initiation of the Phase III trial with ORL-101 in patients with Leukocyte Adhesion Deficiency Type II ("LAD-II"). Orpha Labs AG is working with investigators to switch patients ...