Oddsmakers project the San Francisco 49ers (6-10) to put up a fight in their attempt to break their three-game losing streak, ...

The 49ers have ruled out two key starters versus the Cardinals in the regular season finale. Deebo Samuel and Deommodore ...

Brock Purdy may have cost himself some serious money this season. He wasn't bad, but he wasn't good, either. He was ...

Jennifer Lee Chan shares the latest injury report for Sunday's San Francisco 49ers vs. Arizona Cardinals game.

There are a handful of scenarios where the San Francisco 49ers could come away from Day 1 of the 2025 NFL draft with a ...

See who's in and who's out for the Week 18 matchup between the Arizona Cardinals and San Francisco 49ers on January 5, 2025.

Kyler Murray has started all 16 games for the Cardinals in his first full season back following knee surgery a couple seasons ...

Week 18 will mark the second game Purdy has missed this season, but this time the starter in his stead will be different.

A long, frustrating season for the San Francisco 49ers and Arizona Cardinals is coming to a close. The 49ers visit the ...

The Arizona Cardinals and San Francisco 49ers released their Thursday injury reports ahead of their Week 18 battle. 49ers ...

The Detroit Lions could have rested their starters on Monday night against the San Francisco 49ers with the knowledge that it ...

Joshua Dobbs will replace the injured Brock Purdy as the 49ers' starting quarterback in Sunday's season finale.