3 The founding member of the family, SIRT1, acts on histones in the nucleus to silence ... team found that in keratinocytes, SIRT1 promoted differentiation 5 and inhibited cell proliferation ...

EGFR signaling stabilizes COL17A1 through TIMP1 induction, which is required for cell motility coordinated by actin and keratin filament networks. The age-associated decline of EGFR signaling ...