During culture, chondrocytes can dedifferentiate, losing their ability to produce cartilage-specific extracellular matrix components (73 ... While some studies report the formation of hyaline-like ...

A new therapy that first made headlines in 2021 is now showing potential to heal human cartilage. Developed by scientists at Northwestern University, the technique was initially created to repair ...

We first address the etiopathophysiology of OA and the mechanisms responsible for breakdown of the cartilage extracellular matrix. We then discuss the potential of MSCs for articular cartilage ...

It also presents a novel therapeutic approach for accelerating the healing of defective cartilage and promoting the regeneration of hyaline cartilage ... low cell density, and slow matrix turnover of ...

(28−30) The primary objective of this study is to investigate the efficacy of a novel dual-network hydrogel system composed of LT-GelMA and F127DA in promoting the regeneration of ear cartilage ...

This study highlights lumican as a promising biomarker for predicting the onset and progression of diabetic nephropathy and reveals its close association with extracellular matrix remodeling, a ...