Mechanistically, by binding to the RNA binding protein (RBP) HuR, ZFHX4-AS1 promotes the interaction of HuR and mRNA of the target antisense gene ZFHX4, leading to enhanced ZFHX4 expression.

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in understanding cancer biology.

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in ...

A study has found that an ancient protein motif that binds to nucleic acids is functionally "ambidextrous." This means that ...

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in ...

In a new study published in Cell Reports, researchers at the University of Freiburg reveal how a disordered protein segment ...

Extending this discovery recently in Cell, Flynn and colleagues showed that glycoRNAs form highly organized clusters with RNA-binding proteins on the cell surface. These clusters appear to ...

The labs of Ryan Flynn at Boston Children’s Hospital and Konstantinos Tzelepis at the Cambridge Stem Cell Institute have found a readily druggable target on the surface of acute myeloid leukemia (AML) ...

The structure of the PP7 bacteriophage coat protein revealed a mode of RNA binding that is distinct from that of the well-characterized MS2 coat protein, suggesting new orthogonal systems for RNA ...

Extending this discovery recently in Cell, Flynn and colleagues showed that glycoRNAs form highly organized clusters with RNA-binding proteins on the cell surface. These clusters appear to ...