By integrating CRISPR-Cas9 induced gene editing with single cell RNA-Seq, high-resolution lineage tracing through molecular barcoding ... in silico experiment simulating lineage history from a ...

Lineage tracing allows us to follow the progeny of a single cell to better understand this evolution, including acquisition of genetic lesions, clonal outgrowth, and metastatic spread ...

Many inflammatory stimuli can induce progenitor cells in the bone marrow to produce increased numbers ... HSPCs from IL-27 deficient mice are pre-disposed towards the monocyte lineage. Additional ...

1 Day LCTX 5.57% DJIA 1.23% Russell 2K 2.00% Health Care/Life Sciences -0.64% ...

UHN Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

How alterations in cell metabolism translate into specific developmental gene programs remains a major question. This study ...