Bolt's lead CEA-targeting ISAC comprises a novel, fully human antibody with high affinity and selectivity to CEACAM5 (CEA), and not to other members of the CEACAM family, conjugated to a propriety ...

RxDx assay as a companion diagnostic to identify c-Met protein expression in non-squamous NSCLC patients eligible for treatment with Emrelis.

The cleavable capping technology confines the compound's therapeutic activity to the local tumor microenvironment, thereby potentially increasing the anticipated therapeutic window in patients. The ...

Preclinical research involves the evaluation of potential therapeutic interventions in cells and animals. Candidates for entry into clinical trials can then be selected based on their ...

Tissue expression of neutrophil elastase is better than histologic activity for predicting long-term relapse in patients with ulcerative colitis in remission. The tissue expression level of neutrophil ...

Dato-DXd is an antibody-drug conjugate that combines a humanized anti-TROP2 IgG1 monoclonal antibody with a topoisomerase I inhibitor payload connected by a plasma-stable, cleavable linker. According ...

School of Chemistry and Chemical Engineering, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Jiao Tong University, Shanghai 200240, China ...