Among the major classes of RNAs in the cell, tRNAs remain the most difficult to characterize via deep sequencing approaches, as tRNA structure and nucleotide modifications can each interfere with cDNA ...

Interferon-induced cytoplasmic condensates enriched with ADP-ribosylation ... To determine whether ADPr condensate formation relies on transcription, we treated cells with the inhibitor Actinomycin D.

7 Brigham and Women’s Hospital, Neurology, Boston, MA, United States of America 8 Harvard Medical School, Neurology, Boston, MA, United States of America Background Inclusion body myositis ... CD8+ ...

The use of human cell, mouse, and fly models afforded capture of distinct ... which shows progressive re-distribution to the cytoplasm. The effect of polyQ expansion on the HTT interaction with TCERG1 ...

TAR DNA-binding protein 43, better known as TDP-43, is a protein found in almost all human cells ... accumulates in the cytoplasm where it forms insoluble inclusions, and is depleted from the ...

TAR DNA-binding protein 43, better known as TDP-43, is a protein found in almost all human cells ... accumulates in the cytoplasm where it forms insoluble inclusions, and is depleted from the ...

A pathological variant of MSA, characterized by severe neuronal cytoplasmic inclusions (NCIs), was described by Ando et al. This variant involved hippocampal granule cells, cornu Ammonis areas, the ...

Cells lacking a stiff cell wall, e.g., mammalian cells, must actively regulate their volume to maintain proper cell function. On the time scale that protein production is negligible, water flow in and ...

Over the past decade, there have been scattered reports of mammalian cells’ own DNA being found in the cytoplasm, mainly in the context of disease and aging. While it is not unusual to find DNA from ...

Deletion of the obligate Hedgehog co-receptor, Smoothened, in Sox9-expressing cells prior to injury results in a near-complete loss of callus formation and rib bone regeneration. In contrast to its ...