Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type ...

Endothelial cells provide mass transfer, cholangiocytes transport bile, and Kupffer cells act as a protective barrier. Hepatic stellate cells are located along the specialized blood capillaries of ...

Drug-induced liver injury (DILI) is a significant concern in clinical practice, arising from medications, herbs, and dietary supplements.

Furthermore, UDCA protects cholangiocytes by promoting bile acid excretion, maintaining the integrity of bile ducts, and preventing bile acid-induced cellular damage. UDCA in DILI Treatment and ...

Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix metalloproteases (MMPs) in the hepatic ...

Senescent cholangiocytes exhibit SASP, promoting fibrosis through autocrine and paracrine mechanisms. In Mdr2 (−/−) mice and human PSC samples, p16 and miR-34a were elevated, while SIRT1 levels ...