The cell must also pass through a series of checkpoints that ensure conditions are favorable for division. In order to move from one phase of its life cycle to the next, a cell must pass through ...

factors involved in maintenance of cell cycle checkpoints, and proteins required for apoptosis induction. The types of genetic alterations leading to pRb inactivity most often involve frameshifts ...

In this role-playing game, students act as cells (healthy and cancerous) and go through the cell cycle, while some students play the roles of checkpoint proteins. This experience deepens their ...

cerevisiae and mammalian cells, respectively. Our data suggest that in human cells, the complex acts as a sensor of DNA damage that participates in the activation of cell cycle checkpoints following g ...

The poster will include clinical data as of an April 4, 2025 data cutoff from the Company's ongoing Phase 1/2 clinical trial evaluating azenosertib in combination with encorafenib and cetuximab in ...

Checkpoint activation results in the stabilization of stalled forks, prevents further origin firing, and creates a cellular milieu that promotes the resolution of replication fork blocks before entry ...