Plant breeding plays a vital role in ensuring global food security by increasing crop yields, improving nutritional quality ...

"Our study is a first step in dramatically expanding our repertoire of effective and safe CRISPR-Cas9 enzymes. In our manuscript, we demonstrate the utility of these PAMmla-predicted enzymes to ...

In a new study published in Nature titled, “Custom CRISPR-Cas9 PAM variants via scalable engineering and machine learning,” researchers from Massachusetts General Hospital (MGH) and Harvard ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

CRISPR-Cas systems are prokaryotic immune systems that confer resistance to foreign genetic ... The flexibility of CRISPR/Cas9 editing is severely constrained by the requirement that the ...

It has been 20 years since the term “genome editing” first entered the scientific lexicon, a field that was revolutionized by the development of CRISPR gene editing in 2012. But the remarkable ...

Using blue light to fight drug-resistant infections Date: April 22, 2025 Source: University of Oklahoma Summary: Researchers have made a breakthrough discovery that could potentially revolutionize ...

Ovarian cancer, characterized by its heterogeneity and resistance to conventional therapies such as cisplatin (CDDP), presents a significant clinical challenge. To address these challenges, we ...

The CRISPR specialist said that a single 50mg infusion of NTLA-2002 – which switches off a gene involved in the potentially life-threatening inflammatory attacks that characterise HAE ...

CRISPR-based technologies have taken the world by storm thanks to the technique’s ability to edit nucleic acids. Today, researchers are not only working to understand how to better harness the ...

The specialist in CRISPR-based gene editing – co-founded by Nobel Prize winner Jennifer Doudna – said it is focusing on NTLA-2002 for hereditary angioedema (HAE) and nexiguran ziclumeran (nex ...

Methods: A genome-wide CRISPR-Cas9 knockout (KO) screen was conducted in the SBC ... Conclusion: We identified a novel gene, FBXO11, whose loss results in PARPi resistance in SCLC cell lines. BioID of ...