S, Principal Investigator at A*STAR SRL are co-authors of the study. While the current study focuses on basal cell carcinoma (BCC), researchers believe the technology could also be adapted to ...

INVESTIGATORS AND CLINICIANS anticipate that the next wave of therapeutic approaches in renal cell carcinoma (RCC) will target hypoxia-inducible factor-2 (HIF-2), a transcription factor that is ...

We previously reported that Notch1 activation in committed basal cells triggers a basal-to-luminal cell fate switch in the mouse mammary ... Given the roles of Notch signaling in cancer, these results ...

in the treatment of basal cell carcinoma (BCC), with positive data outcomes. The study included patients who had relapsed after standard therapies and had no other treatment options. Among them, three ...

CX-4945 Monotherapy: Progression-free survival (PFS) exceeded 21 months in two patients. Optimal Treatment Response: Three patients achieved partial response (PR), while ten patients had stable ...

How do dermatologists diagnose squamous cell skin cancer? When you see a board-certified dermatologist for a spot that might be skin cancer, your dermatologist will examine your skin carefully. If ...

Major Finding: A cancer-associated fibroblast (CAF)–epithelial cell niche shields squamous cell carcinomas (SCC) from antitumor immune responses. Concept: Epithelial JAG1–NOTCH1 signaling promotes the ...

A high proportion of HNSCC cases are attributable to HPV. An estimated 70% of the 20,000 cases of oropharyngeal squamous cell carcinoma (HNSCC that occurs in the oropharynx) seen annually in the ...

CA9 is a cell surface antigen highly expressed in ~95% of ccRCC with minimal expression in normal tissues, making it an attractive target for diagnosis and treatment. PeptiDream and its wholly owned ...