The Detroit Lions probably didn’t have to play their starters on Monday night, but did, and the blueprint for the rest of their season became clearer. The Lions can score a lot of points.

Jared Goff and the Detroit Lions visit Levi’s Stadium for the final home game of this injury-riddled 49ers season Click to share on Facebook (Opens in new window) Click to share on Twitter ...

SANTA CLARA -- The 49ers just lost 40-34 to the Detroit Lions. Here are the 49ers' grades for this emabarrassing performance. Brock Purdy was an extreme version of the quarterback he has been all ...

The Detroit Lions scored on five consecutive drives in the second half to pull away for a 40-34 win over the host San Francisco 49ers on the final "Monday Night Football" matchup of the season.

Either way, we’ll likely hear their names often on Monday Night Football, as one of those newcomers will be protecting 49ers’ quarterback Brock Purdy’s blindside against the Lions.

Brock Purdy threw for a career-high 377 yards and three touchdowns as the San Francisco 49ers fell to the Detroit Lions 40-34 at Levi's Stadium on Monday Night Football. Purdy also threw two ...

SANTA CLARA, Calif. -- After missing last week because of a hamstring injury, San Francisco 49ers running back Isaac Guerendo is set to play Monday night against the Detroit Lions. Guerendo ...

And last year, Campbell suffered the most crushing defeat of his head-coaching career when the Lions lost the NFC championship game to the San Francisco 49ers. They built a 17-point halftime lead ...

One reason the 49ers haven't been good this season is their inability to create turnovers on defense. It's been an issue, especially in their last month of games. It's been one of the biggest ...

Lions 40, 49ers 34, final: The 49ers score a touchdown but can’t recover the onside kick as the Lions hold on for their 14th win of the season. Jared Goff threw for 300 yards, Jahyr Gibbs ran ...