Promoter sequences are DNA sequences that define where transcription of a gene by RNA polymerase begins. Promoter sequences are typically located directly upstream or at the 5' end of the ...

with the first referring to the generally recognized E1 and E2 boxes and the second number representing all CANNTG sequences up to position –400 or the 5' limit of available promoter sequence.

It is essential that new human ß-cell lines be developed and widely distributed in order that physiologically and medically relevant studies on the human insulin promoter can be carried out.