Grey's Anatomy is one of the longest-running TV shows, and in this guide, we discuss what the cast is up to then vs now.

When Grey's Anatomy took off as a cultural phenomenon in the mid-2000s, Patrick Dempsey's Dr. Derek Shepherd also swiftly became one of the biggest heartthrobs on television. Nicknamed "McDreamy ...

Between Jason Isaacs' prosthetic penis, the two brothers hooking up and the cattiness of Jaclyn, Kate and Laurie in 'The ...

Kate Walsh played Derek Shepherd's ex-wife, Dr. Addison Montgomery, on the series from 2005-2012 Georgia Slater is a staff editor on the Parents team at PEOPLE. She has been working at PEOPLE ...

Shonda Rhimes considered creating a "Scandal" spinoff focusing on Eli Pope (Joe Morton) and additional spinoffs for "Grey's Anatomy." ...

When we tuned into the “How to Save a Life” episode of Grey’s Anatomy on April 23, 2015, we had no idea what we were in for, ...

Fans immediately fell in love with Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, George O’Malley, Derek Shepherd, Miranda Bailey, and more. Grey’s Anatomy is now in its 17th season ...

Throughout the medical drama's run, Meredith Grey has mainly lived in two homes: the childhood home she inherited, with a constant rotation of roommates, and the dream house Derek Shepherd built ...

Shonda Rhimes initially thought the scandal surrounding Isaiah Washington’s 2007 firing would get ‘Grey’s Anatomy’ canceled ...

The 28-year-old officer had been called to the scene with his colleague, PC Derek Shepherd, after reports of three men assaulting an occupant. PC Shepherd was also shot and injured during the incident ...