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Put simply: if you take a “T” shaped pipe and pass a fluid (such as air or water) through the straight section, a vacuum will be created on the shorter side due to the Venturi effect.
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The Venturi effect is described as a decrease in pressure when blood flows through a stenosis at a high velocity. This relates to the hemodynamics in hypertrophic obstructive cardiomyopathy (HOCM).