β-GLUCOSE pentaacetate in acetone solution can be partially deacetylated by cooled 1 N potassium hydroxide solution to yield 6-O-acetyl-α-glucose. This product has a melting point of 146°.

These observations led to the discovery of acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), the two key enzymes of fatty acid synthesis. His laboratory was the first to identify these ...