Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

spironolactone, triamterene). The primary risk of eplerenone is hyperkalemia (which can cause serious arrhythmias). Periodic monitoring of potassium levels is recommended for patients at risk of ...

Spironolactone is contraindicated in patients with hyperkalemia, Addison's disease, or concomitant use of eplerenone (Inspra) ...

Spironolactone was initiated at a dose of ... with the use of more-selective agents, such as eplerenone, and studies on these selective agents should be conducted accordingly.

Aldosterone antagonists (spironolactone, eplerenone) also known as “potassium sparing diuretics” block the action of aldosterone inhibiting the reuptake of sodium and water. Normally ...