With their 10th loss of the year Monday night, a 40-34 loss to the Detroit Lions, the 49ers have clinched a last-place schedule in 2025 no matter what happens in their Week 18 game against the 7-9 Arizona Cardinals. That means they’ll face the last-place finishers in the NFC North, NFC East and AFC North.

The San Francisco 49ers' Week 17 loss to the Detroit Lions officially locked the team into last place in the NFC West, regardless of the outcome of their

With Week 16 in the books, we can project the 49ers’ 2025 schedule which looks on paper to be a much easier road than their 2024 slate. If the 49ers finish in last place, they’ll host the last place team in the NFC North, and visit the last place clubs in the NFC East and AFC North. They’ll also face all four teams from the NFC and AFC South.

The San Francisco 49ers' 2024 season is almost over and, following their Monday Night Football loss to the Detroit Lions in Week 17, they now know the identity of every team they will face in 2025. With the defeat to the Detroit,