Andrew Fire and Craig Mello first demonstrated RNAi in C. elegans in 1998, a discovery recognized in 2006 when they won the Nobel Prize in Physiology or Medicine.1 Interest exploded in 2001 when ...

RNAi in Plants I take exception with your claim in The Scientist1 that RNAi was first discovered in Caenorhabditis elegans. While the term "RNAi" was first coined by Fire and colleagues,2 several ...

Figure 2: A model for RNAi/PTGS/quelling. Several laboratories that study C. elegans have initiated genome-wide screens, based on an RNAi approach, to identify genes essential for completion of ...

Oregon Health & Science University, in collaboration with Oregon State University, has discovered the structural organization ...

Our search for additional microRNAs was precipitated by Pasquinelli and Ruvkun's finding that the let-7 RNA sequence is perfectly ... developmental switch in C. elegans. Cell 57, 49–57 (1989).

the C. elegans ortholog of TDP-43, results in an abnormal accumulation of double-stranded RNA (Saldi et al, 2014). We are currently testing the hypothesis that loss of TDP-43 nuclear function, as well ...

Our primary approach has been to develop transgenic C. elegans strains that express these human proteins, often resulting in abnormal phenotypes that can be the basis of classic genetic screens. The ...