medium chain acyl-CoA dehydrogenase deficiency; MMA, methylmalonic acidemia; NAGS, N-acetylglutamate synthetase deficiency; OTC, ornithine transcarbamylase deficiency; PCD, pyruvate carboxylase ...

Here they show that reduced pyruvate dehydrogenase (PDH) activity lowers locomotion but extends lifespan in daphnids and show that inhibition of PDH can increase lifespan in these species.

pyruvate carboxylase deficiency; VLCADD, very long chain acyl-CoA dehydrogenase deficiency. Adapted with permission from Ward JC. Inborn errors of metabolism of acute onset in infancy. Pediatr Rev ...