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Research uncovers specific protein interactions needed for cells to break down and remove damaged mitochondria
The monobodies prevented OPTN accumulation at the mitophagy contact sites. This subsequently blocked TBK1 activation and, thereby, mitochondrial degradation. These experiments further emphasized ...
Nature5d
Mitophagy articles from across Nature Portfolio
Compromised clearance of dysfunctional mitochondria, through the process of mitophagy, has garnered attention as an essential contributor to aging and neurodegeneration. Schmid and colleagues 1 ...